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Mad in America: Rethinking Mental Health

Science Under Pressure, Humanity at Stake: An Interview with John Ioannidis

The Mad in America podcast, hosted by James Moore, examines mental health with a critical eye by speaking with psychologists, psychiatrists and people with lived experience.

When you hear such conversations, you realise that much of what is believed to be settled in mental health is actually up for debate. Is mental health a matter of faulty biology or is there more to it? Are the treatments used in psychiatry helpful or harmful in the long term? Are psychiatric diagnoses reliable? With the help of our guests, we examine these questions and so much more.

This podcast is part of Mad in America’s mission to serve as a catalyst for rethinking psychiatric care and mental health. We believe that the current drug-based paradigm of care has failed our society and that scientific research, as well as the lived experience of those who have been diagnosed with a psychiatric disorder, calls for profound change.

On the podcast over the coming weeks, we will have interviews with experts and those with lived experience of the psychiatric system. Thank you for joining us as we discuss the many issues around rethinking mental health around the world.

For more information visit madinamerica.com

Science Under Pressure, Humanity at Stake: An Interview with John Ioannidis

Sep 10, 2025

John Ioannidis is a Stanford professor, a physician, and one of the most eminent scholars in the world in the field of evidence-based medicine.

Ioannidis has spent his career exposing the weak foundations of much of modern medicine. His 2005 paper, "Why Most Published Research Findings Are False," became the most-viewed article in the history of PLOS Medicine and helped spark a global reckoning with reproducibility. He has since warned about how evidence-based medicine can be hijackedby industry influence, how biased reward systems in academia favor quantity over quality, and how even systematic reviews can recycle flawed data. His critiques extend to psychiatry, where pharma-funded trials often tilt toward positive results, guidelines are shaped by insiders, and neuroscience findings are more fragile than they appear.

He is a tenured professor at Stanford and has an extensive background in medicine, epidemiology, population health, and data sciences. As much as he is a champion of good science, Ioannidis is also a lover of the arts and humanities. He's a novelist, teaches poetry, loves operas, and has written libretti for four operas himself.

In this interview, he discusses the extensive bias that pervades scientific research, the problematic practices and pressures that enable flawed science, and the significant issues with antidepressant research. At the same time, he reminds us why good science is a gift to humanity and something we must protect for our well-being and dignity.

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To find the Mad in America podcast on your preferred podcast player, click here: https://pod.link/1212789850